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Tatara Nanotechnology Project CenterDirector　Takuya OHBA, Professor, Interdisciplinary Graduate School of Science and EngineeringTheme　Study on new methods of quantitative analysis of complex microstructures in steel and ironOutline　Tatara is traditional steel making process developed in Japan. Our project aims to crystallographic research in metals. One of our recent research results are related to microstructure of steels performed by Prof. S. Morito as below. Tool and cutlery Steels, which excel in high strength and hardness, have complex microstructures composed of fine crystals. The complex microstructures enhance not only strength but also toughness. We can create steel with higher strength and toughness by controlling the microstructures. However, it is difficult to identify the microstructures because of their finesse and complexity. Now we are trying to analyze the microstructures with three dimensional observations and automatic analysis methods employing crystallographic measurements. We are also searching for the formative mechanism and structural mechanism of the microstructures to control them.Project Center for Comprehensive Research on Congenital AnomaliesDirector　Hiroki OTANI, Professor, Faculty of MedicineTheme　Organ dysmorphology as results of accumulated polarity disruptions in epithelial tubular structures during organogenesis “SUIGANN” Project CenterDirector　Takeshi URANO, Professor, Faculty of MedicineTheme　Antibody drug preparation against pancreatic cancerOutline　Morbidity for the pancreatic carcinoma in Shimane Prefecture is on a high level in Japan. It is a highly lethal cancer; mortality for the disease is also high. More than 90% of patients die within 5 years of their diagnosis and 75% of patients die within the first year. The mortality rate in Shimane prefecture is above the national average. Since it is a disease whose prognosis is extremely poor compared with other cancers, development of novel treatment methods is desired. Shimane University Hospital is taking a leading part in multidisciplinary, fundamental/clinical researchers with the aim of eradicating the pancreatic cancer. We will make a number of monoclonal antibodies for early diagnosis and/or treating the disease.Ancient Izumo Project CenterDirector　Yasuo OHASHI, Professor, Faculty of Law and LiteratureTheme　Study of Izumo Fudoki (description of the culture, climate etc. of Izumo province) and Its Acceptance, and Formation of The Center for Historical and Cultural Studies in Eastern Asia and Pacific AreaDirector　Hirotaka OKAMURA, Associate Professor, Center for Foreign Language EducationTheme　International Joint Research on History and Traditional Culture for Community Revitalization in Eastern Asia and Pacific AreaOutline　A study of History of Ancient Chinese thoughts using excavated materialsThe purpose of this study is to obtain a new view about the history of Ancient Chinese thoughts by analyzing excavated materials in the Warring States period, Qin period and Han period. The Guodian Chu Slips were unearthed in 1993 in Tomb No.1 of the Guodian tombs in Jingmen, Hubei Province, made public later in 1998 and they were dated to the latter half of the Warring States period. In 1994, Shanghai Museum collected the Chu bamboo Slips dating to the Warring States period. In 2007, The Yuelu Academy of Hunan University acquired bamboo Slips dating to Qin period. In 2008, Tsinghua University acquired bamboo Slips dating to the Warring States period. Further, Beijing University acquired bamboo Slips in 2009 dating to Han period and bamboo Slips in 2010 dating to Qin period. By using these numerous discoveries, the history of Ancient China is now being rewritten. Particularly we have been analyzing how the ideas around Qi氣（気）, which is an important idea in the Chinese philosophy, developed in the Pre-Qin period, as well as the issue of the shape and structure of the bamboo slips.Outline　Malformations of organs are the abnormalities in position, shape, and/or size of the organs along the three-dimensional body axes as the results of accumulated abnormalities in various polarities at the cellular and tissue levels. In this project, we elucidate the mechanisms by which abnormalities in the polarity regulation in the epithelial tubular structures accumulate during development and result in malformations of the organs.and histogenesisthe Image of Ancient IzumoOutline　We are pursuing a comprehensive study on the formation and development of the areal province in the process of formation of “Izumo Province” in a multifaceted way by utilizing methods of document-based historical research, archaeology, and geology. Especially we concentrate on reconstructing the image of ancient Izumo by investigating how the unit of a “local area” was formed by researching timeless historical data.As one of the main subjects, we are making investigation and researches of local administrative offices centering around the Izumo provincial government, which was deeply related with the formation of Ancient Izumo. The local administrative system of ancient Japan is represented by the structure of areal administrative offices centering around the provincial government. We therefore try to elucidate when the provincial government was established and how its structure was.36For more information on researchers and research activities at Shimane University, visit https://www.staffsearch.shimane-u.ac.jp/kenkyu/(a) Three dimensional image of martensite. (b) Blue part ‘martensite’ of (a) is drawn separately for understanding its distribution.Project Centers